Rearrarrangement of spiro[benzocyclobutene-1,3′-piperidines]
✍ Scribed by Georg von Sprecher; Tammo Winkler
- Book ID
- 104226392
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 140 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The spirocyclic indoline ring system represents an important scaffold for the discovery of novel therapeutics. Herein, we describe the synthesis of 1,1 0 -H-spiro[indoline-3,3 0 -piperidine] using an intramolecular palladium-catalyzed a-arylation reaction.
## Abstract The title compounds **14–16** were obtained __via__ an intramolecular __Mannich__ condensation by treating **11–13** with CH~2~O at RT. The unsaturated ketones **14** and **15** were reduced to the allylic alcohols **18** and **19** respectively. Ring cleavage of compound **18** on trea