𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Spiro piperidines. 1. Synthesis of spiro[isobenzofuran-1(3H),4'-piperidin]-3-ones, spiro[isobenzofuran-1(3H),4'-piperidines], and spiro[isobenzotetrahydrothiophene-1(3H),4'-piperidines]

✍ Scribed by Parham, William E.; Egberg, David C.; Sayed, Y. A.; Thraikill, Robert W.; Keyser, Gene E.; Neu, Martha.; Montgomery, William C.; Jones, Lawrence D.


Book ID
126439724
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
721 KB
Volume
41
Category
Article
ISSN
0022-3263

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Convenient synthesis of 1,1β€²-H-spiro[ind
✍ Jeffrey A. Pfefferkorn; Chulho Choi πŸ“‚ Article πŸ“… 2008 πŸ› Elsevier Science 🌐 French βš– 153 KB

The spirocyclic indoline ring system represents an important scaffold for the discovery of novel therapeutics. Herein, we describe the synthesis of 1,1 0 -H-spiro[indoline-3,3 0 -piperidine] using an intramolecular palladium-catalyzed a-arylation reaction.

3-(4-MethylΒ­piperidin-1-yl)isobenzofuran
✍ BΓΌyΓΌkgΓΌngΓΆr, Orhan ;Odabaşoğlu, Mustafa πŸ“‚ Article πŸ“… 2006 πŸ› International Union of Crystallography 🌐 English βš– 245 KB

The crystal structure of the title compound, C~14~H~17~NO~2~, is stabilized by three intermolecular Cβ€”H...O hydrogen bonds and one π–π interaction. Cβ€”H...O hydrogen bonds generate an edge-fused [__R__ ~3~ ^3^(13)__R__ ~4~ ^2^(14)__R__ ~3~ ^3^(13)] ring motif.