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Sphingosine-1-phosphate signaling in physiology and diseases

✍ Scribed by Yoh Takuwa; Yasuo Okamoto; Kazuaki Yoshioka; Noriko Takuwa

Book ID: 112009909
Publisher: IOS Press
Year: 2012
Tongue: English
Weight: 354 KB
Volume: 38
Category: Article
ISSN: 0951-6433
DOI: 10.1002/biof.1030

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## Abstract **Background:** The bioactive sphingolipid sphingosine 1‐phosphate (S1P) is formed by the activation of sphingosine kinase (SPHK) in diverse stimuli, such as platelet‐derived growth factor (PDGF). S1P acts not only as an extracellular mediator but also as an intracellular second messeng