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Cellular signalling by sphingosine kinase and sphingosine 1-phosphate

✍ Scribed by Tamara M. Leclercq; Stuart M. Pitson

Book ID: 111741827
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 579 KB
Volume: 58
Category: Article
ISSN: 1521-6543
DOI: 10.1080/15216540600871126

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## Abstract **Background:** The bioactive sphingolipid sphingosine 1‐phosphate (S1P) is formed by the activation of sphingosine kinase (SPHK) in diverse stimuli, such as platelet‐derived growth factor (PDGF). S1P acts not only as an extracellular mediator but also as an intracellular second messeng