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Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis

✍ Scribed by Yuki Kariya; Akio Kihara; Mika Ikeda; Fumiaki Kikuchi; Seiichi Nakamura; Shunichi Hashimoto; Chang-Hwan Choi; Yong-Moon Lee; Yasuyuki Igarashi


Book ID
108731774
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
273 KB
Volume
10
Category
Article
ISSN
1356-9597

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## Abstract Glial cell line‐derived neurotrophic factor (GDNF) is important for the development and maintenance of dopamine neurons (Lin et al. [1993] Science 260: 1130–1132). GDNF is neuroprotective in animal models of Parkinson disease, where dopamine neurons show selective degeneration. We previ