In Xenopus oocytes, both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) activate Ca2+-dependent oscillatory Cl- currents by acting through membrane-bound receptors. External application of 50 microM S1P elicited a long-lasting oscillatory current that continued over 30 min from the be
✦ LIBER ✦
Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: Regulation of synovial proliferation and inflammatory gene expression
✍ Scribed by Masayasu Kitano; Timothy Hla; Masahiro Sekiguchi; Yutaka Kawahito; Rikio Yoshimura; Keiji Miyazawa; Tsuyoshi Iwasaki; Hajime Sano
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 533 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0004-3591
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## Abstract G protein‐coupled receptors (GPCRs) for lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P) transduce signals to many functions of normal cells. Most human cancer cells upregulate S1P and LPA GPCRs, in patterns distinctive for each type of tumor. The findings that 1‐alpha, 25‐