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Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis

✍ Scribed by Harunori Takeshita; Masayasu Kitano; Tsuyoshi Iwasaki; Sachie Kitano; Sachi Tsunemi; Chieri Sato; Masahiro Sekiguchi; Naoto Azuma; Keiji Miyazawa; Timothy Hla; Hajime Sano

Book ID
116302962
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
620 KB
Volume
419
Category
Article
ISSN
0006-291X

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## Abstract G protein‐coupled receptors (GPCRs) for lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P) transduce signals to many functions of normal cells. Most human cancer cells upregulate S1P and LPA GPCRs, in patterns distinctive for each type of tumor. The findings that 1‐alpha, 25‐