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Palmitoylation of the sphingosine 1-phosphate receptor S1P1 is involved in its signaling functions and internalization

✍ Scribed by Yusuke Ohno; Ayako Ito; Ren Ogata; Yuki Hiraga; Yasuyuki Igarashi; Akio Kihara


Book ID
110091048
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
548 KB
Volume
14
Category
Article
ISSN
1356-9597

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In Xenopus oocytes, both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) activate Ca2+-dependent oscillatory Cl- currents by acting through membrane-bound receptors. External application of 50 microM S1P elicited a long-lasting oscillatory current that continued over 30 min from the be