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Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS

โœ Scribed by Laura J. Sim-Selley; Paulette B. Goforth; Mba U. Mba; Timothy L. Macdonald; Kevin R. Lynch; Sheldon Milstien; Sarah Spiegel; Leslie S. Satin; Sandra P. Welch; Dana E. Selley


Book ID
111183530
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
847 KB
Volume
110
Category
Article
ISSN
0022-3042

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In Xenopus oocytes, both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) activate Ca2+-dependent oscillatory Cl- currents by acting through membrane-bound receptors. External application of 50 microM S1P elicited a long-lasting oscillatory current that continued over 30 min from the be