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Spermine–nucleic acid interactions: A theoretical study

✍ Scribed by Krystyna Zakrzewska; Bernard Pullman

Publisher
Wiley (John Wiley & Sons)
Year
1986
Tongue
English
Weight
844 KB
Volume
25
Category
Article
ISSN
0006-3525

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✦ Synopsis

The interaction of spermine with nucleic acids is simulated theoretically using refined semiempirical energy formulae and an advanced minimization procedure. Various nucleic acids are considered: model homopolymeric DNA's, a dodecamer (CGCGAATTCGCG) of type B-DNA, as well as a transfer RNA, tRNAPhe. The dominant role of electrostatic potential in determining the preferential binding sites of spermine is demonstrated in each of these cases and the role of counterions, nucleic acid structure, and base-pair sequence is analyzed.

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