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Spectrophotometric Microdetermination of Ampicillin and Amoxicillin with Picric and Picramic Acids

✍ Scribed by A.S. Amin; M.E. Moustafa; Y.M. Issa


Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
277 KB
Volume
50
Category
Article
ISSN
0026-265X

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✦ Synopsis


Ampicillin trihydrate ((12.5-575 \mu \mathrm{g})) and amoxycillin trihydrate ((10-400 \mu \mathrm{g})), in (25-\mathrm{ml}) total volume, are determined spectrophotometrically using picric and picramic acids as (\pi)-acceptors at (\mathrm{pH} 9). The method is relatively accurate (with a recovery of (100 \pm 1.67 %) ) and precise ((\mathrm{RSD}=1.7 %)) and was applied successfully to capsules, ampoules, and syrup formulations. 1994 Academic Press, Inc.


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