𝔖 Bobbio Scriptorium
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Specificity of zinc binding to myelin basic protein

✍ Scribed by P. Riccio; S. Giovannelli; A. Bobba; E. Romito; A. Fasano; T. Bleve-Zacheo; R. Favilla; E. Quagliariello; P. Cavatorta


Publisher
Springer
Year
1995
Tongue
English
Weight
964 KB
Volume
20
Category
Article
ISSN
0364-3190

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## Abstract In order to determine the peptide bond specificity of calpain, human myelin basic protein (HMBP) was treated with purified calpain of bovine brain. Upon incubation, HMBP component I (HMBP‐1) was degraded into several peptides as demonstrated by sodium dodecy1 sulfate‐polyacrylamide gel

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Several recently discovered lines of evidence support the involvement of my elin basic protein (BP)-specific T cells in multiple sclerosis (MS). To identify potentially relevant immunodominant T cell epitopes, human BP (Hu-BP)-reactive T cell lines were selected from MS and normal donors and tested