Species-specificity and localization of encephalitogenic sites in myelin basic protein
β Scribed by Kies, MarianW.
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 615 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0344-4325
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## Abstract In order to determine the peptide bond specificity of calpain, human myelin basic protein (HMBP) was treated with purified calpain of bovine brain. Upon incubation, HMBP component I (HMBPβ1) was degraded into several peptides as demonstrated by sodium dodecy1 sulfateβpolyacrylamide gel
The epitope specificities of myelin basic protein (BP) specific T cell lines derived from the spinal cords (SC) and lymph nodes (LN) of rats with experimental autoimmune encephalomyelitis (EAE) were compared. To induce EAE, Lewis rats were immunized with guinea pig (GP)-BP and complete Freund's adju