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Specific tritium labelling of sphingosines at the 3-position

✍ Scribed by Rolf Birk; Gerald Brenner–Weiß; Atanassios Giannis; Konrad Sandhoff; Richard R. Schmidt

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
332 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Azidosphingosines 4A,B are transformed with DDQ into the corresponding keto derivatives 6A,B. Reduction of the keto group with [^3^H]NaBH~4~ and then conversion of the azido group into the amino group by Staudinger reaction yields stereoselectively the D‐erythro‐and L‐threo‐sphingosines 9A,B, 10A,B, respectively.

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