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Specific systemic nonviral gene delivery to human hepatocellular carcinoma xenografts in SCID mice

✍ Scribed by Markus F. Wolschek; Christiane Thallinger; Malgorzata Kursa; Vanessa Rössler; Matthew Allen; Cornelia Lichtenberger; Ralf Kircheis; Trevor Lucas; Martin Willheim; Walter Reinisch; Alfred Gangl; Ernst Wagner; Burkhard Jansen

Book ID
111722028
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
432 KB
Volume
36
Category
Article
ISSN
0270-9139

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Effect of a xanthine analog on human hep
Effect of a xanthine analog on human hepatocellular carcinoma cells (Alexander) in culture and in xenografts in SCID mice
✍ L Marucci; L Varticovski; I M Arias 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 671 KB

Hepatocellular carcinoma (HCC) frequently overexpresses the MDR1 gene and is resistant to drugs transported by the multidrug-resistance efflux pump. A xanthine analog, 1-(11-dodecylamino-10-hydroxyundecyl)-3,7-dimethylxanthine (CT-2584,CTI), is cytotoxic to many tumors in culture and was four times