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Effect of a xanthine analog on human hepatocellular carcinoma cells (Alexander) in culture and in xenografts in SCID mice

✍ Scribed by L Marucci; L Varticovski; IM Arias

Book ID
118686734
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
671 KB
Volume
26
Category
Article
ISSN
0270-9139

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Effect of a xanthine analog on human hep
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✍ L Marucci; L Varticovski; I M Arias πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 671 KB

Hepatocellular carcinoma (HCC) frequently overexpresses the MDR1 gene and is resistant to drugs transported by the multidrug-resistance efflux pump. A xanthine analog, 1-(11-dodecylamino-10-hydroxyundecyl)-3,7-dimethylxanthine (CT-2584,CTI), is cytotoxic to many tumors in culture and was four times

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## Abstract Amooranin (AMR), a natural triterpenoid drug isolated and characterized from __Amoora rohituka__ stem bark, is cytotoxic to SW620 human colon carcinoma cell line with an IC~50~ value of 2.9 ΞΌg/ml. This novel compound caused depolarization of mitochondrial membrane and decrease of membra