Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC
โ Scribed by Mulligan, Lois M.; Eng, Charis; Healey, Catherine S.; Clayton, David; Kwok, John B.J.; Gardner, Emily; Ponder, Margaret A.; Frilling, Andrea; Jackson, Charles E.; Lehnert, Hendrik
- Book ID
- 109914913
- Publisher
- Nature Publishing Group
- Year
- 1994
- Tongue
- English
- Weight
- 582 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1061-4036
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๐ SIMILAR VOLUMES
## Communicated by Martin Bobrow The RET proto-oncogene codes for a receptor tyrosine kinase thought to play a role in the development of neural crest and its derivatives. Mutations in the RET proto-oncogene have been found in patients with the multiple endocrine neoplasia type 2 syndromes (MEN 2)
Communicated by B w e A.J. Pondei Multiple endocrine neoplasia type 2 [MEN 21 is an autosomal dominant cancer syndrome with two subtypes, 2A and 2B. MEN 2A and medullary thyroid cancer [MTC] are caused by >25 different point mutations in exons 10, 11, and 13 of the RET proto-oncogene, whereas MEN 2B