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Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC

โœ Scribed by Mulligan, Lois M.; Eng, Charis; Healey, Catherine S.; Clayton, David; Kwok, John B.J.; Gardner, Emily; Ponder, Margaret A.; Frilling, Andrea; Jackson, Charles E.; Lehnert, Hendrik


Book ID
109914913
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
582 KB
Volume
6
Category
Article
ISSN
1061-4036

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Mutations of the RET proto-oncogene in t
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## Communicated by Martin Bobrow The RET proto-oncogene codes for a receptor tyrosine kinase thought to play a role in the development of neural crest and its derivatives. Mutations in the RET proto-oncogene have been found in patients with the multiple endocrine neoplasia type 2 syndromes (MEN 2)

Diagnosis of multiple endocrine neoplasi
โœ Marios Kambouris; Charles E. Jackson; Gerald L. Feldman ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 1006 KB

Communicated by B w e A.J. Pondei Multiple endocrine neoplasia type 2 [MEN 21 is an autosomal dominant cancer syndrome with two subtypes, 2A and 2B. MEN 2A and medullary thyroid cancer [MTC] are caused by >25 different point mutations in exons 10, 11, and 13 of the RET proto-oncogene, whereas MEN 2B