Germline mutations of the RET proto-oncogene in eight Japanese patients with multiple endocrine neoplasia type 2A (MEN2A)
β Scribed by Syuya Takiguchi-Shirahama; Kumiko Koyama; Akira Miyauchi; Takanobu Wakasugi; Seiichi Oishi; Hiroshi Takami; Kazumasa Hikiji; Yusuke Nakamura
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 473 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0340-6717
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π SIMILAR VOLUMES
## Communicated by Martin Bobrow The RET proto-oncogene codes for a receptor tyrosine kinase thought to play a role in the development of neural crest and its derivatives. Mutations in the RET proto-oncogene have been found in patients with the multiple endocrine neoplasia type 2 syndromes (MEN 2)
Communicated by B w e A.J. Pondei Multiple endocrine neoplasia type 2 [MEN 21 is an autosomal dominant cancer syndrome with two subtypes, 2A and 2B. MEN 2A and medullary thyroid cancer [MTC] are caused by >25 different point mutations in exons 10, 11, and 13 of the RET proto-oncogene, whereas MEN 2B
## Communicated b~ R.G.H. Cotton Activating germline mutations in the cysteine-rich domain of the RET proto-oncogene cause endocrine neoplasia type 2A, an autosomal dominant inherited cancer syndrome affecting cells derived from the neural crest, including medullary thyraid carcinoma