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Novel germline mutations of theMEN1gene in Japanese patients with multiple endocrine neoplasia type 1

โœ Scribed by K. Hamaguchi; Nguyen Duc Cong; Toshihiko Yanase; Shoichiro Ikuyama; Kiminobu Goto; Ryoichi Takayanagi; Hajime Nawata; Yoichiro Kusuda; Koji Fukagawa; Toshiie Sakata


Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
224 KB
Volume
44
Category
Article
ISSN
1435-232X

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Germline mutations in the multiple endoc
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Multiple endocrine neoplasia type 1 (MEN 1) is a familial cancer syndrome characterized by parathyroid hyperplasia, pituitary adenomas, and neuroendocrine tumors of the pancreas and duodenum. In 1997, the MEN1 tumor suppressor gene was identified, and numerous germline mutations have been reported t

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Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by tumors in parathyroids, enteropancreatic endocrine tissues, anterior pituitary, and other tissues. The gene for MEN1 has recently been cloned and shown to code for a 610-amino acid protein of enigmatic func