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NovelMEN1gene mutations in familial multiple endocrine neoplasia type 1

โœ Scribed by A. Sakurai; Shuya Shirahama; Minoru Fujimori; Miyuki Katai; Yasunori Itakura; Shinya Kobayashi; Jun Amano; Yoshimitsu Fukushima; Kiyoshi Hashizume


Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
90 KB
Volume
43
Category
Article
ISSN
1435-232X

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Multiple endocrine neoplasia type 1
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Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disease characterized by neoplasia of the parathyroid glands, anterior pituitary and endocrine pancreas, is rarely reported in Asian populations. The MEN1 gene, mapped to chromosome 11q13 but yet to be cloned, has been found to be hom

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Multiple endocrine neoplasia type 1 (MEN 1) is a familial cancer syndrome characterized by parathyroid hyperplasia, pituitary adenomas, and neuroendocrine tumors of the pancreas and duodenum. In 1997, the MEN1 tumor suppressor gene was identified, and numerous germline mutations have been reported t