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Duplication of 9 base pairs in the critical cysteine-rich domain of the RET proto-oncogene causes multiple endocrine neoplasia type 2A

✍ Scribed by Dr. Wolfgang Höppner; Henning Dralle; Georg Brabant

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 475 KB
Volume: 11
Category: Article
ISSN: 1059-7794
DOI: 10.1002/humu.1380110143

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✦ Synopsis

Communicated b~ R.G.H. Cotton

Activating germline mutations in the cysteine-rich domain of the RET proto-oncogene cause endocrine neoplasia type 2A, an autosomal dominant inherited cancer syndrome affecting cells derived from the neural crest, including medullary thyraid carcinoma

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✍ Charis Eng; Lois M. Mulligan 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 225 KB 👁 2 views

## Communicated by Martin Bobrow The RET proto-oncogene codes for a receptor tyrosine kinase thought to play a role in the development of neural crest and its derivatives. Mutations in the RET proto-oncogene have been found in patients with the multiple endocrine neoplasia type 2 syndromes (MEN 2)