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Specific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides

✍ Scribed by Laptev, A.V.; Lu, Z.; Colige, A.; Prockop, D.J.


Book ID
122755741
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
90 KB
Volume
14
Category
Article
ISSN
0945-053X

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Thiono triester modified antisense oligo
✍ Zhaoda Zhang; Jean A. Smith; Adrienne P. Smyth; Warren Eisenberg; Gregory S. Par πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 348 KB

A series of thiono triester containing oligonucleotide phosphorothioates linked with a lipophilic group have been successfully synthesized. Some of these modified antisense oligonucleotides show potent anti-HCMV activity as well as improved cellular association and nuclease resistance.