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A 1.9-Kb 5' Fragment from the Human COL1A1 Gene Drives Inappropriate Expression of the Human COL2A1 Gene in Tissues of Trangenic Mice that Normally Express Only the COL1A1 Gene

✍ Scribed by Leena Ala-Kokko; Constance M. Yuan; Dominique Le Guellec; Suzanne Franc; Andrzej Fertala; Jaspal S. Khillan; Boris P. Sokolov; Darwin J. Prockop

Book ID
119873783
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
99 KB
Volume
785
Category
Article
ISSN
0890-6564

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Development of the vertebrate skeleton is a highly complex process in which collagen type II plays a vital role in the formation of long bones via endochondral ossification. Collagen type II, which is encoded by a single COL2A1/ Col2a1 gene, is the most abundant structural protein in the cartilage m