✦ LIBER ✦

Thiono triester modified antisense oligonucleotides for inhibition of human cytomegalovirus in vitro

✍ Scribed by Zhaoda Zhang; Jean A. Smith; Adrienne P. Smyth; Warren Eisenberg; Gregory S. Pari; Jin Yan Tang

Book ID: 103983497
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 348 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00335-6

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✦ Synopsis

A series of thiono triester containing oligonucleotide phosphorothioates linked with a lipophilic group have been successfully synthesized. Some of these modified antisense oligonucleotides show potent anti-HCMV activity as well as improved cellular association and nuclease resistance.

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