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Specific cytotoxic effect of neocarzinostatin conjugated to monoclonal antibody A7 on human pancreatic carcinoma

โœ Scribed by Otsuji, Eigo ;Takahashi, Toshio ;Yamaguchi, Toshiharu ;Yamaguchi, Nozomi ;Imanishi, Jiro


Publisher
Springer-Verlag
Year
1990
Tongue
English
Weight
560 KB
Volume
25
Category
Article
ISSN
0435-1339

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The anticancer agent neocarzinostatin (NCS) was bound covalently to human/mouse chimeric Fab fragments of the monoclonal antibody A7 to form the conjugate chA7Fab-NCS. The antitumor effect of chA7Fab-NCS was tested by measuring the inhibition of 3H-thymidine incorporation into human pancreatic carci

Intratumoral administration of neocarzin
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## Abstract We investigated the following in athymic nude mice with xenografts of a human pancreatic carcinoma: 1) clearance of the murine monoclonal antibody A7 from the carcinoma; and 2) the antitumor effect of neocarzinostatin conjugated to MAb A7 (A7โ€NCS) on the carcinoma following intratumoral