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Intratumoral administration of neocarzinostatin conjugated to monoclonal antibody A7 in a model of pancreatic cancer

✍ Scribed by Dr. Eigo Otsuji; Toshiharu Yamaguchi; Nobuki Yamaoka; Kazuya Kitamura; Nozomi Yamaguchi; Toshio Takahashi

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
533 KB
Volume
53
Category
Article
ISSN
0022-4790

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✦ Synopsis

Abstract

We investigated the following in athymic nude mice with xenografts of a human pancreatic carcinoma: 1) clearance of the murine monoclonal antibody A7 from the carcinoma; and 2) the antitumor effect of neocarzinostatin conjugated to MAb A7 (A7‐NCS) on the carcinoma following intratumoral injection. Compared with ^125^I‐labeled normal mouse IgG, a significantly larger amount of ^125^I‐labeled A7 remained in the tumor after intratumoral injection. Neocarzinostatin conjugated to MAb A7 showed a greater antitumor activity against human pancreatic cancer than neocarzinostatin alone after intratumoral administration. The conjugate completely suppressed tumor growth macroscopically during the experiment. Tumor tissue in mice became necrotic 32 days after injection with A7‐NCS. These observations suggest that the intratumoral injection of A7‐NCS offers promise in treating pancreatic carcinoma. Β© 1993 Wiley‐Liss, Inc.

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