Specific Complement-Fixing Tumor Antigens in Human Cells Morphologically Transformed by SV40 Virus
β Scribed by Albert B. Sabin, H. M. Shein, Meinrad A. Koch and John F. Enders
- Book ID
- 123657952
- Publisher
- National Academy of Sciences
- Year
- 1964
- Tongue
- English
- Weight
- 185 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/72482
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## Abstract The effect of immunization with fetal antigens and tumorβspecific antigens on the transplantation of SVT2, a BALB/c mouse tumor induced by Simian virus 40 (SV40), has been studied. Hyperimmunization with 5,000 R Xβirradiated, syngeneic fetuses of 1β2 weeks' gestation or syngeneic spleen
Sera from hamsters bearing tumors induced by papovavirus SV40 reacted with tumor antigen prepared either from cells transformed by, or from cells infected with, the homologous virus. Serum titers against both antigens were comparable. A high degree of correlation was obtained with the use of either