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Specific binding of radioiodinated human GM-CSF to the blast cells of acute myeloblastic leukemia

✍ Scribed by Ikuo Murohashi; Shuji Tohda; Toshiya Suzuki; Kaoru Nagata; Yoko Yamashita; Nobuo Nara


Book ID
113239120
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
524 KB
Volume
13
Category
Article
ISSN
0145-2126

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Recombinant hemopoietic colony-stimulating factors (CSFs), including GM-CSF, G-CSF and IL-3, have been shown to be effective stimulators of both self-renewal and terminal differentiation of blast stem cells in acute myeloblastic leukemia (AML). We have examined the activity of a fourth growth factor

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## Abstract Blast cells from patients with Acute Myeloblastic Leukemia (AML) were separated according to cell size using velocity sedimentation under unit gravity. Fractions obtained in this way were plated in methyl cellulose with a growth stimulator present in media conditioned by leukocytes in t