✦ LIBER ✦

The effects of recombinant CSF-1 on the blast cells of acute myeloblastic leukemia in suspension culture

✍ Scribed by Jun Miyauchi; Chen Wang; Colm A. Kelleher; Gordon G. Wong; Steven C. Clark; Mark D. Minden; Ernest A. McCulloch

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 866 KB
Volume: 135
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041350108

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✦ Synopsis

Recombinant hemopoietic colony-stimulating factors (CSFs), including GM-CSF, G-CSF and IL-3, have been shown to be effective stimulators of both self-renewal and terminal differentiation of blast stem cells in acute myeloblastic leukemia (AML). We have examined the activity of a fourth growth factor, recombinant CSF-1 (or M-CSF), on the growth of leukemic blasts in culture. CSF-1 was found to be active on some, but not all, blast populations. In sensitive cells, CSF-1 often stimulated the production of adherent blast cells incapable of division. This observation leads us to suggest that CSF-1 may be useful in the treatment of selected cases of AML.

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