Spatial relationship of phosphorylated epidermal growth factor receptor and activated AKT in head and neck squamous cell carcinoma
โ Scribed by Monique M. Nijkamp; Ilse J. Hoogsteen; Paul N. Span; Robert P. Takes; Jasper Lok; Paul F. Rijken; Albert J. van der Kogel; Johan Bussink; Johannes H.A.M. Kaanders
- Book ID
- 118498041
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 742 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0167-8140
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## Abstract ## Background Cumulative evidence implicates the epidermal growth factor receptor (EGFR) as an important therapeutic target in head and neck squamous cell carcinoma (HNSCC). The basis for the lack of correlation between EGFR expression in the HNSCC tumor and clinical responses to EGFR
## Abstract The degree of gene amplification for epidermal growth factor receptor (EGFR) and its expression levels were examined in 4 cases of tumor lesions and their cell lines of human squamous cell carcinoma (SCC) of the oral cavity. The amplification was detected in 1 case (ZA), but not signifi