Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy
β Scribed by Jonathan Rosand; Alona Muzikansky; Ashok Kumar; Jonathan J. Wisco; Eric E. Smith; Rebecca A. Betensky; Steven M. Greenberg
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 606 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0364-5134
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We examined the potential role of the extra-cellular matrix-degrading enzyme, matrix metalloproteinase-9 (MMP-9), in the pathogenesis of cerebral amyloid angiopathy (CAA)-induced spontaneous hemorrhage. The amyloid-beta peptide (Abeta) induced the synthesis, release and activation of MMP-9 in murine