Matrix metalloproteinase–9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy
✍ Scribed by Jin-Moo Lee; Ke-Jie Yin; Idar Hsin; Shawei Chen; John D. Fryer; David M. Holtzman; Chung Y. Hsu; Jian Xu
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 175 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0364-5134
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✦ Synopsis
We examined the potential role of the extra-cellular matrix-degrading enzyme, matrix metalloproteinase-9 (MMP-9), in the pathogenesis of cerebral amyloid angiopathy (CAA)-induced spontaneous hemorrhage. The amyloid-beta peptide (Abeta) induced the synthesis, release and activation of MMP-9 in murine cerebral endothelial cells, resulting in increased extracellular matrix degradation. Furthermore, extensive MMP-9 immunoreactivity was observed in CAA-vessels with evidence of microhemorrhage in aged APPsw transgenic mice, but not detected in aged wild type or young APPsw mice. These results suggest that increased vascular MMP-9 expression, stimulated by Abeta, may play a role in the pathogenesis of spontaneous intracerebral hemorrhage in patients with CAA.