✦ LIBER ✦

Spasmolytic Activity of Cissampelous mucronata Leaf Extract

✍ Scribed by V. N. Offiah; P. A. Akah; A. O. Isizoh

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 287 KB
Volume: 10
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199606)10:4<322::aid-ptr801>3.0.co;2-3

No coin nor oath required. For personal study only.

✦ Synopsis

The aqueous leaf extract of Cissampelous mueronata (Menispermaceae) was studied for spasmolytic properties. The extract inhibited the responses of histamine, acetylcholine and nicotine on the guinea-pig ileum in a doserelated manner. The extract completely abolished the spontaneous pendular movement of the rabbit jejunum reversibly, and decreased gastrointestinal motility in mice. It did not modify the effect of Ca2+ on the guinea-pig ileum. Acute toxicity tests in mice established the i.p. LD, value of the extract to be 1698.24*77 mg/kg.

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