A model of hypertriglyceridaemia in rats is described, which was used to investigate the hypolipidaemic effect of an intraperitoneal (i./p.) administration of a Ficus carica leaf decoction. Hypertriglyceridaemia was induced in rats following the protocol: a fasting period of 22 h, 2 h of oral (p.o.
Hypolipidaemic Activity of Ficus carica Leaf Extract in Streptozotocin-diabetic Rats
β Scribed by E. Dominguez; J. R. Canal; M. D. Torres; J. E. Campillo; C. Perez
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 221 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0951-418X
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β¦ Synopsis
A decoction of Ficus cwicu Significantly lowered plasma triglyceride levels in rats with insulin-dependent diabetes (streptozotocin sOmg/kg body weight) when it was administered orally (357*206mg/dL before administration and 81 *81 mg/dL 3 weeks after administration,p<O.Ol, n =ll). The plasma triglyceride levels in diabetic rats were also lower when the Gicur c&u extract was administered intraperitoneally (608k391 mg/dL before administration; 444*310 mg/dL 90 min after administration; and 106*129 mg/dL 48 h after administration; p<0.005, n =7). The cholesterolaemia remained unchanged.
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