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Sorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis

โœ Scribed by M Hennenberg; J Trebicka; C Stark; AZ Kohistani; J Heller; T Sauerbruch


Book ID
111218198
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
345 KB
Volume
157
Category
Article
ISSN
0007-1188

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In liver cirrhosis, down-regulation of endothelial nitric oxide synthase (eNOS) has been implicated as a cause of increased intrahepatic resistance. We investigated whether Rho-kinase activation is one of the molecular mechanisms involved in defective eNOS signaling in secondary biliary cirrhosis. L