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Endothelin-1 derived from spleen-activated Rho-kinase pathway in rats with secondary biliary cirrhosis

✍ Scribed by Hideo Uehara; Tomohiko Akahoshi; Hirohumi Kawanaka; Naotaka Hashimoto; Yoshihiro Nagao; Morimasa Tomikawa; Akinobu Taketomi; Ken Shirabe; Makoto Hashizume; Yoshihiko Maehara

Book ID: 114944031
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 250 KB
Volume: 42
Category: Article
ISSN: 1386-6346
DOI: 10.1111/j.1872-034x.2012.01021.x

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In liver cirrhosis, down-regulation of endothelial nitric oxide synthase (eNOS) has been implicated as a cause of increased intrahepatic resistance. We investigated whether Rho-kinase activation is one of the molecular mechanisms involved in defective eNOS signaling in secondary biliary cirrhosis. L