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Some kinetic and thermodynamic characteristics of apomorphine degradation

✍ Scribed by A. M. Burkman

Publisher
John Wiley and Sons
Year
1965
Tongue
English
Weight
185 KB
Volume
54
Category
Article
ISSN
0022-3549

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✦ Synopsis

Rates of spontaneous apomorphine degradation have been determined at varying temperature and pH under pseudo first-order conditions. T h e p H profile, covering a range of pH 5.2 t o 6.8 at 30Β°, describes the influence of the reaction of aqueous media o n apomorphine stability. Buffering the medium to lower pH values dramatically decreases the velocity of decomposition. Rate constants have been determined for reactions run at 0.2 p H unit intervals over the range described. Rates calculated at a constant pH 6.0 but at different temperatures (30' and 40') provide data for the estimation of the heat of activation, which was computed to be 12,057 cal./mole.

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