✍ Scribed by Judyta Cielecka-Piontek; Anna JelińSka; Agnieszka Dołhań; Przemysław Zalewski
No coin nor oath required. For personal study only.
The kinetic and thermodynamic parameters of degradation of doripenem were studied using a high-performance liquid chromatography method. In dry air, the degradation of doripenem was a first-order reaction depending on the substrate concentration. At increased relative air humidity, doripenem was degraded according to the autocatalysis kinetic model. The dependence ln k = f(1/T ) was described by the equations ln k = 5.10 ± 13.06 -(7576 ± 4939)(1/T ) in dry air and ln k = 46. 70 ± 22.44 -(19,959 ± 8031)(1/T ) at 76.4% relative humidity (RH). The thermodynamic parameters E a , H =a , and S =a of the degradation of doripenem were calculated. The dependence ln k = f (RH%) was described by the equation ln k = (0.155 ± 0.077) × 10 -1 (RH%) -(3.45 ± 21.8) × 10 -10 .
📜 SIMILAR VOLUMES
A change in the constitution of the tetracationic cyclophane components (comprised of two paraquat residues bridged by either m-or p-phenylene rings) in [2]catenanes, where the other macrocyclic components are polyethers (incorporating two p-electronrich rings, such as 1,4-dioxybenzene or 1,5-dioxyn
Though there is an advantage in using the higher solubility amorphous state in cases where low solubility limits absorption, physical instability poses a significant barrier limiting its use in solid oral dosage forms. Unlike chemical instability, where useful accelerated stability testing protocols