✦ LIBER ✦

Degradation of hyaluronic acid—Kinetic study and thermodynamics

✍ Scribed by Yuichi Tokita; Akio Okamoto

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 303 KB
Volume: 32
Category: Article
ISSN: 0014-3057
DOI: 10.1016/0014-3057(96)00019-5

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✦ Synopsis

The hydrolytic degradation of hyaluronic acid (HA) was investigated by kinetic measurements. The first-order rate constants of the hydrolytic degradation of HA at different pH and temperature were obtained on the basis of the decrease in the molecular weight of HA. In addition, from the rate constant, we obtained the activation entropy (AS+) and enthalpy (AH*), and under all conditions studied the experimental data gave linear plots according to an isokinetic relationship.

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