The hydrolytic degradation of hyaluronic acid (HA) was investigated by kinetic measurements. The first-order rate constants of the hydrolytic degradation of HA at different pH and temperature were obtained on the basis of the decrease in the molecular weight of HA. In addition, from the rate constan
Hydrolytic degradation of hyaluronic acid
β Scribed by Y. Tokita; A. Okamoto
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 379 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0141-3910
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## Abstract A novel protocol to control the molecular degradation of hyaluronic acid (HA) hydrogels was successfully developed for tissue augmentation applications. HA has a different conformational structure in water and organic solvent, and the carboxyl group of HA is known to be the recognition