Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis
β Scribed by Pharoah, P D P; Day, N E; Caldas, C
- Book ID
- 110002415
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 78 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0007-0920
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Polymorphisms in phase I and phase II enzymes may enhance the occurrence of mutations at critical tumor suppressor genes, such as __p53__, and increase breast cancer risk by either increasing the activation or detoxification of carcinogens and/or endogenous estrogens. We analyzed polymo
The prognostic significance of p53 gene abnormalities was investigated in 9 I9 primary breast-cancer patients. p53 expression and tumour-cell proliferation fraction determined by MIB-I count, p53 exon 5 and 6 mutations and HER-Z/neu oncogene amplification were detected by immunohistochemistry, PCR-S