p53 mutation, deprivation and poor prognosis in primary breast cancer
β Scribed by Baker, L; Quinlan, P R; Patten, N; Ashfield, A; Birse-Stewart-Bell, L-J; McCowan, C; Bourdon, J-C; Purdie, C A; Jordan, L B; Dewar, J A
- Book ID
- 110000342
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 351 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0007-0920
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## Abstract Acquired mutations in __TP53__ as well as immunohistochemically detectable protein expression have been implicated as prognostic factors for breast cancer. We have evaluated the relationship between mutations detected in 119 breast tumours and various clinicohistopathological indices, s
We intended to establish the frequency of exon-specific TP53 gene alterations and the relation t o patient and tumor characteristics and clinical outcome of patients with breast cancer. By using polymerase chain reaction-single-strand conformation polymorphism analysis (KR-SSCP) and sequencing techn