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Somatic mutation of the β2-microglobulin gene associates with unfavorable prognosis in gastrointestinal cancer of the microsatellite mutator phenotype

✍ Scribed by Hiroyuki Yamamoto; Kentaro Yamashita; Manuel Perucho


Book ID
119756237
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
591 KB
Volume
120
Category
Article
ISSN
0016-5085

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## Abstract The 1100delC mutation of the cell cycle checkpoint kinase 2 (__CHEK2__) gene confers an increased risk for breast cancer, but the clinical impact of other __CHEK2__ gene variants remains unclear. We determined the frequency of two functionally relevant __CHEK2__ gene mutations, I157T an