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Somatic mutation of the PTEN/MMAC1 gene in breast cancers with microsatellite instability

✍ Scribed by Kaori Minobe; Koichi Bando; Koichi Fukino; Sachi Soma; Fujio Kasumi; Goi Sakamoto; Kiyonori Furukawa; Katsuyoshi Higuchi; Masahiko Onda; Yusuke Nakamura; Mitsuru Emi

Book ID: 117469543
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 199 KB
Volume: 144
Category: Article
ISSN: 0304-3835
DOI: 10.1016/s0304-3835(99)00181-0

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## Abstract Microsatellite instability (MSI) and mutations in the PTEN gene are among the molecular alterations involved in endometrial carcinogenesis. There is conflicting information regarding to their role in this type of tumor. For this reason, we have studied both molecular lesions in a large