Somatic frameshift mutations of bone morphogenic protein receptor 2 gene in gastric and colorectal cancers with microsatellite instability
β Scribed by SANG WOOK PARK; SOO YOUNG HUR; NAM JIN YOO; SUG HYUNG LEE
- Book ID
- 109344104
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 285 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0365-5555
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## Abstract We have systematically retrieved genes with coding mononucleotide repeats from sequence databases and analyzed them for mutations in tumors with high levels of microsatellite instability (MSIβH). We found somatic frameshift mutations in 7/13 genes previously not analyzed in MSIβH tumors
Overexpression of cyclooxygenase-2 (COX-2) has been reported in gastric cancers. However, the relationship between expression of COX-2 and clinico-pathological or genotypic features has not been elucidated. To address the issue, expression of COX-2 protein was analyzed in 100 gastric cancers as well
Forty-three sporadic gastric cancers were analyzed with regard to whether mutations of simple repeated sequences in the transforming growth factor fi type II receptor ( T p -I / ) gene are associated with microsatellite instability (MSI) and gastric carcinogenesis. In 12 ofthe 43 cancers (28%), MSI