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Frameshift mutation of SIRT1 gene in gastric and colorectal carcinomas with microsatellite instability

✍ Scribed by YOO RI KIM; SUNG SOO KIM; NAM JIN YOO; SUG HYUNG LEE


Book ID
109343995
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
111 KB
Volume
118
Category
Article
ISSN
0365-5555

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## Abstract We have systematically retrieved genes with coding mononucleotide repeats from sequence databases and analyzed them for mutations in tumors with high levels of microsatellite instability (MSI‐H). We found somatic frameshift mutations in 7/13 genes previously not analyzed in MSI‐H tumors