✦ LIBER ✦

Somatic cell hybrids between totipotent mouse teratocarcinoma and rat hepatoma cells

✍ Scribed by Gerald Litwack; Carlo M. Croce

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 809 KB
Volume: 101
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041010102

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We have produced somatic cell hybrids between totipotent mouse teratocarcinoma cells and rat hepatoma cells. These hybrids were tested for the expression of liver specific functions expressed in the hepatoma cell parent and for their ability to differentiate when injected into nude mice. The results of this study indicate that hybrid cell clones do not resemble either of the parental cells, since they do not produce albumin and tyrosine aminotransferase that are expressed in the rat hepatoma parent, and are incapable of forming either teratocarcinoma or hepatomas when injected in experimental animals.

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