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Epstein-barr virus in somatic cell hybrids between mouse cells and human nasopharyngeal carcinoma cells

✍ Scribed by Zenon Steplewski; Hilary Koprowski; Maria Andersson-Anvret; George Klein

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
618 KB
Volume
97
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Somatic cell hybrids between mouse cells and cells derived directly from NPC biopsies were produced in order to study the association of the Epstein‐Barr virus (EBV) genome and the expression of Epstein‐Barr nuclear antigen (EBNA) with the human chromosome(s). All attempts to correlate the presence of EBV‐DNA and the expression of EBNA with the presence of a particular human chromosome(s) showed that the segregation of EBV‐DNA or of EBNA and human chromosomes was dysconcordant. The data, therefore, suggest that in the hybrids studied the presence of EBA‐DNA is not determined by the presence of a specific human chromosome.

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