Solvent-free synthesis of α-aminonitriles from aldehydes, amines and trimethylsilyl cyanide catalyzed by thallium(III) chloride tetrahydrate

✍ Scribed by Anjoy Majhi; Sung Soo Kim; Santosh T. Kadam

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 163 KB
• Volume: 22
• Category: Article
• ISSN: 0268-2605
• DOI: 10.1002/aoc.1463

✦ Synopsis

Abstract

A straightforward and efficient method has been developed for the synthesis of α‐aminonitriles by combining aldehydes, amines and trimethylsilyl cyanide in the presence of a catalytic amount of thallium(III) chloride tetrahydrate (1 mol%) under solvent‐free conditions at room temperature. Copyright © 2008 John Wiley & Sons, Ltd.