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One-Pot Diastereoselective Synthesis of α-Aminonitriles from Aldehydes, Chiral Amines, and Trimethylsilyl Cyanide under Solvent-Free Conditions.

✍ Scribed by A. Kazemeini; N. Azizi; M. R. Saidi


Publisher
John Wiley and Sons
Year
2006
Weight
19 KB
Volume
37
Category
Article
ISSN
0931-7597

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Solvent-free synthesis of α-aminonitrile
✍ Anjoy Majhi; Sung Soo Kim; Santosh T. Kadam 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 163 KB

## Abstract A straightforward and efficient method has been developed for the synthesis of α‐aminonitriles by combining aldehydes, amines and trimethylsilyl cyanide in the presence of a catalytic amount of thallium(III) chloride tetrahydrate (1 mol%) under solvent‐free conditions at room temperatur